PMID:
J Dent Sci. 2018 Dec ;13(4):334-341. Epub 2018 Jul 20. PMID: 30895142
Abstract Title:
Acemannan increased bone surface, bone volume, and bone density in a calvarial defect model in skeletally-mature rats.
Abstract:
Background/purpose: Acemannan, aβ-(1-4)-acetylated polymannose extracted fromgel, has been proposed as biomaterial for bone regeneration. The aim of this study was to investigate the effect of acemannan in calvarial defect healing.Materials and methods: Acemannan was processed to freeze-dried sponge form and disinfected by UV irradiation. Thirty-five female Sprague-Dawley rats were used in thestudy. Seven-mm diameter mid-calvarial defects were created and randomly allocated into blood clot control (C), acemannan 1 mg (A1), 2 mg (A2), 4 mg (A4), and 8 mg (A8) groups (n = 7). After four weeks, the calvarial specimens were subjected to microcomputed tomography (microCT) and histopathological analysis.Results: MicroCT revealed a significant increase in bone surface and bone volume in the A1 and A2 groups, and tissue mineral density in the A4 and A8 groups compared with the control group (
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