Sulforaphane inhibited proliferation of bladder cancer cells by 29.7 ± 4.6% under normal oxygen conditions and 48.3 ± 5.2% under hypoxic conditions through suppression of HIF-1α-mediated glycolysis.

PMID: 

J Agric Food Chem. 2019 Jul 17 ;67(28):7844-7854. Epub 2019 Jul 9. PMID: 31241937

Abstract Title: 

Sulforaphane Inhibits Nonmuscle Invasive Bladder Cancer Cells Proliferation through Suppression of HIF-1α-Mediated Glycolysis in Hypoxia.

Abstract: 

Bladder cancer is the fourth common cancer among men and more than 70% of the bladder cancer is nonmuscle invasive bladder cancer (NMIBC). Because of its high recurrence rate, NMIBC brings to patients physical agony and high therapy costs to the patients' family and society. It is imperative to seek a natural compound to inhibit bladder cancer cell growth and prevent bladder cancer recurrence. Cell proliferation is one of the main features of solid tumor development, and the rapid tumor cell growth usually leads to hypoxia due to the low oxygen environment. In this study we found that sulforaphane, a natural chemical which was abundant in cruciferous vegetables, could suppress bladder cancer cells proliferation in hypoxia significantly stronger than in normoxia (

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