PMID:
Electromagn Biol Med. 2013 Mar ;32(1):1-8. Epub 2012 Oct 9. PMID: 23046051
Abstract Title:
Exposure of rats to extremely low-frequency electromagnetic fields (ELF-EMF) alters cytokines production.
Abstract:
Investigations indicate a potential link between exposure to extremely low-frequency electromagnetic field (ELF-EMF) and some cancers. Carcinogenesis of ELF-EMF may be mediated by effect on the immune system. During an immune response, naïve T cells differentiate to effector type 1 helper T cells (T(H)1), T(H)2, or T(H)17 subsets according to existence of different cytokines and T(H)1 is important in defense against tumors. Therefore, it will be reasonable to test whether ELF-EMF can change cytokines like interferon gamma (IFN-γ),interleukin-4 (IL-4), IL-6, and IL-12 that regulate T(H)1/T(H)2/T(H)17 balance. Forty adult male rats were randomly separated into ELF-EMF-exposed and sham-exposed control groups. The ELF-EMF group was exposed to a flux density of 100 μT, frequency 50 Hz, 2 h/day for 3 months. The controls wereplaced in identical chamber without ELF-EMF. The results showed there were no significant differences between the mean mass of rats, thymuses, and spleens in ELF-EMF exposed group compared with controls. Serum IL-12 level was decreased from 418 ± 47 pg/ml in controls to 300 ± 23 pg/ml (p
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