PMID:
Antioxidants (Basel). 2019 Aug 1 ;8(8). Epub 2019 Aug 1. PMID: 31374912
Abstract Title:
Lion's Mane Mushroom,(Bull.: Fr.) Pers. Suppresses HO-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia.
Abstract:
Oxidative stress and inflammation in neuron-glia system are key factors in the pathogenesis of neurodegenerative diseases. As synthetic drugs may cause side effects, natural products have gained recognition for the prevention or management of diseases. In this study, hot water (HE-HWA) and ethanolic (HE-ETH) extracts of the basidiocarps ofmushroom were investigated for their neuroprotective and anti-inflammatory activities against hydrogen peroxide (HO)-induced neurotoxicity in HT22 mouse hippocampal neurons and lipopolysaccharide (LPS)-induced BV2 microglial activation respectively. HE-ETH showed potent neuroprotective activity by significantly (
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