These findings provide evidence supporting the importance of adequate physiological vitamin E status for lung cancer risk reduction.

PMID: 

J Natl Cancer Inst. 2019 May 11. Epub 2019 May 11. PMID: 31077299

Abstract Title: 

A Prospective Study of Serum Vitamin E and 28-Year Risk of Lung Cancer.

Abstract: 

BACKGROUND: Epidemiologic data are inconsistent regarding the vitamin E-lung cancer association, and no study has examined serologic changes in vitamin E status in relation to subsequent risk.METHODS: In a cohort of 22,781 male smokers in the ATBC Study, we ascertained 3,184 lung cancer cases during up to 28 years of observation. Cox proportional hazards models examined whether higher serum alpha-tocopherol concentrations at baseline, 3 years, or the interval change were associated with lower lung cancer risk. All statistical tests were two-sided.RESULTS: After adjustment for age, body mass index, smoking intensity and duration, serum total cholesterol, and trial intervention group, we found lower lung cancer risk in men with high baseline alpha-tocopherol (5th quintile (Q5) vs Q1, hazard ratio (HR)=0.76, 95%CI =0.66 to 0.87; Ptrend

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