PMID:
J Food Biochem. 2019 Mar ;43(3):e12758. Epub 2019 Jan 3. PMID: 31353546
Abstract Title:
Effect of Horse-chestnut seed extract on matrix metalloproteinase-1 and -9 during diabetic wound healing.
Abstract:
The effects of aqueous-ethanol extract of Horse chestnut (HCE) on MMP-1 and MMP-9 expressions during cutaneous wound healing in diabetic rats were investigated in this study. The expressions of MMP-1 and MMP-9, wound closure, myeloperoxidase (MPO) activity, hydroxyproline, and malondialdehyde (MDA) levels in wound tissue were measured. Quercetin glucuronide in HCE was identified as main compound using a LC-MS/MS. The hydroxyproline level was significantly increased in the treated group versus control after the 3rd and 7th days (p
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