PMID:
Complement Ther Med. 2019 Aug ;45:89-97. Epub 2019 May 23. PMID: 31331588
Abstract Title:
Policosanol supplementation significantly improves blood pressure among adults: A systematic review and meta-analysis of randomized controlled trials.
Abstract:
BACKGROUND AND AIMS: Policosanol contains a mixture of concentrated primary aliphatic alcohols extracted from sugar cane wax and is recognized as a cholesterol-lowering drug but previous studies reported that it could be helpful for reducing blood pressure as well. We aimed to systematically review all randomized control trials (RCTs) evaluating the efficacy of policosanol supplementation for lowering high blood pressure.METHODS AND RESULTS: The following databases were searched up to March 2019: PubMed, Scopus, ISI Web of Science and the Cochrane library. Eligible RCTs were included if they investigate the effects of policosanol supplementation on systolic (SBP) and diastolic (DBP) blood pressure. Pooled effect size was measured using random effect model (DerSimmonon method). A total of nineteen studies with twenty-four arms were considered. Pooled effect size showed that SBP (WMD: -3.423 mmHg, 95% CI: -5.315, -1.531; p
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