PMID:
Avicenna J Phytomed. 2019 Jul-Aug;9(4):386-395. PMID: 31309076
Abstract Title:
Cytotoxic and anti-proliferative effects ofSchrenk extracts on human liver and breast cancer cells.
Abstract:
Objective: Schrenk has been consumed in Iranian traditional medicine. In contrary to its close species (e.g.), there is no data on its medicinal properties. Therefore, we explored possible cytotoxic effects ofagainst two cancer cell lines.Materials and Methods: The cytotoxic and anti-proliferative effects ofethanolic and aqueous extracts on human liver cancer cells (LCLPI 11), breast cancer cells (MCF-7) and fibroblast-like cells (HSkMC) were evaluated by MTT, BrdU and TUNEL assays.Results: Following 48 h, ICvalues for LCL-PI11 and MCF-7 cells were found to be 3.9 and 4.2μg/mL for aqueous extract, and 2.3 and 2.7 μg/mL for ethanolic extract, respectively.BrdU assay data verified the MTT results and showed that both extracts inhibit cell proliferation as much as 5-fluorouracil does (p
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