A subgroup of patients with mitochondrial disease may be at risk of autistic regression with fever.

PMID: 

J Child Neurol. 2010 Apr ;25(4):429-34. Epub 2009 Sep 22. PMID: 19773461

Abstract Title: 

Fever plus mitochondrial disease could be risk factors for autistic regression.

Abstract: 

Autistic spectrum disorders encompass etiologically heterogeneous persons, with many genetic causes. A subgroup of these individuals has mitochondrial disease. Because a variety of metabolic disorders, including mitochondrial disease show regression with fever, a retrospective chart review was performed and identified 28 patients who met diagnostic criteria for autistic spectrum disorders and mitochondrial disease. Autistic regression occurred in 60.7% (17 of 28), a statistically significant increase over the general autistic spectrum disorder population (P

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