PMID:
Anticancer Agents Med Chem. 2019 Jul 4. Epub 2019 Jul 4. PMID: 31272362
Abstract Title:
Ginsenoside Rh2 Inhibits Migration of Lung Cancer Cells Under Hypoxia via mir-491.
Abstract:
BACKGROUND: Ginsenoside Rh2 (Rh2), which is extracted form ginseng, exerts antitumor activity. Here we would like to study the role of Rh2 on hypoxia-induced migration in lung adenocarcinoma.METHODS: Lung adenocarcinoma A549 and H1299 cells were cultured in 1% O2 condition to mimic the hypoxic tumor microenvironment. The migrations of cancer cells were measured by transwell assay and scratch assay.RESULTS: Rh2 could inhibit hypoxia -induced A549 and H1299 cell migration via increase of mir-491expression. Further, mir-491 antisense oligonucleotide could repress hypoxia-induced migration and the expression of matrix metalloproteinase (MMP)-9 expression in Rh2-treated A549 cells.CONCLUSION: These findings suggest that Rh2 exerts anti-metastasis activity in hypoxic tumor microenvironment in lung adenocarcinoma cells via mir-491.
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