PMID:
Cent Nerv Syst Agents Med Chem. 2017 ;17(2):116-122. PMID: 27554922
Abstract Title:
Anticancer, Antioxidant and Cytotoxic Potential of Thymol in vitro Brain Tumor Cell Model.
Abstract:
BACKGROUND: Thymol (THY), which is a monocyclic monoterpene, found in oil of thyme various other kinds of plants. Until today, although different biological properties of THY have been indicated, its neurological toxicity has never been investigated.METHOD: In this study, in vitro antiproliferative (by 3-(4,5 dimetylthiazol-2-yl)-2,5 diphenlytetrazolium bromide (MTT) test), genotoxic (by single cell gel electrophoresis (SCGE)) and oxidative effects (by total antioxidant capacity (TAC) and total oxidative status (TOS) analysis) of THY (0-400 mg/L) were assessed on cultured primary rat neurons (CPRNs) and N2a neuroblastoma cells.RESULTS: The obtained data from MTT analysis revealed that THY (only at 400 mg/L) led to significant (p0.05) in both treated cell type as compared to control group. The present results also showed that 10, 25 and 50 mg/L of THY application into the cell cultures supported antioxidant capacity in primary rat neurons but not in N2a cells.CONCLUSION: In a conclusion, these results confirm that THY may have antiproliferative potential against brain tumor cells involving oxidative alteration.
Health Time 