PMID:
Mutat Res. 2011 Dec 24 ;726(2):136-45. Epub 2011 Sep 14. PMID: 21933721
Abstract Title:
In vivo radioprotective potential of thymol, a monoterpene phenol derivative of cymene.
Abstract:
The radioprotective and anticlastogenic potential of a phenol derivative monoterpene thymol(TOH), against whole-body gamma radiation was studied in Swiss albino mice. Acute toxicity of TOH, with an LD(50(14)) of 1134.03mg/kgbwt., was observed when administered intra-peritoneally (i.p.). The radioprotective potential of TOH was evaluated using the optimal dose of 10mg/kgbwt. TOH, which increased the LD(50/30) by 2.17Gy and resulted in a dose reduction factor (DRF) of 1.25. A significant (p
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