PMID:
Nutrients. 2018 Sep 14 ;10(9). Epub 2018 Sep 14. PMID: 30223488
Abstract Title:
Bergamot Polyphenol Fraction Exerts Effects on Bone Biology by Activating ERK 1/2 and Wnt/β-Catenin Pathway and Regulating Bone Biomarkers in Bone Cell Cultures.
Abstract:
Epidemiological studies show that fruit consumption may modulate bone mineral density. However, data regarding the effect of theRisso (Bergamot orange), a citrus fruit containing a high concentration of flavonoids, on bone health are still lacking. In this study, we investigated the effects of Bergamot polyphenols on the Wnt/β-catenin pathway in two distinct bone cell types (Saos-2 and MG63). Findings showed that exposure to 0.01 and 0.1 mg/mL doses upregulate β-catenin expression (= 0.001), osteoblast differentiation markers (e.g.,and), and downregulate RANKL (= 0.028), as compared to the control. Our results highlight, for the first time, that Bergamot polyphenols act on bone cells through theβ-catenin pathway. In vivo studies are necessary to fully understand Bergamot's role against bone resorption.
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