PMID:
FASEB J. 2019 Aug 20:fj201900386RR. Epub 2019 Aug 20. PMID: 31431058
Abstract Title:
Coenzyme Qalleviates tacrolimus-induced mitochondrial dysfunction in kidney.
Abstract:
The major side effect of tacrolimus (Tac) is nephrotoxicity. We studied whether supplementation of coenzyme Q, (CoQ) a potent antioxidant, can reduce Tac-induced nephrotoxicityimproving mitochondrial function. In anstudy, CoQreduced the production of Tac-induced mitochondrial reactive oxygen species and abolished the loss of mitochondrial membrane potential in proximal tubular cell line. Assessment of mitochondrial function revealed that CoQdecreased oxygen consumption and mitochondrial respiration rate increased by Tac, suggesting improvement of mitochondrial function to synthesize ATP with CoQtreatment. The effect of the CoQstudy was observed in an experimental model of chronic Tac-induced nephropathy. CoQattenuated Tac-induced oxidative stress and was accompanied by function and histologic improvement. On electron microscopy, addition of CoQincreased not only the number but also the volume of mitochondria compared with Tac treatment only. Our data indicate that CoQimproves Tac-induced mitochondrial dysfunction in kidney. Supplementary CoQtreatment may be a promising approach to reduce Tac-induced nephrotoxicity.-Yu, J. H., Lim, S. W., Luo, K., Cui, S., Quan, Y., Shin, Y. J., Lee, K. E., Kim, H. L., Ko, E. J., Chung, B. H., Kim, J. H., Chung, S. J., Yang, C. W. Coenzyme Q10 alleviates tacrolimus-induced mitochondrial dysfunction in kidney.
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