PMID:
Ann Vasc Surg. 2019 Aug 23. Epub 2019 Aug 23. PMID: 31449943
Abstract Title:
Resveratrol normalizes the deterioration of smooth muscle contractility following intestinal ischemia and reperfusion in rats associated with an anti-oxidative effect and modulating TNF-α activity.
Abstract:
BACKGROUND: The aim of the current study was to investigate the effect of resveratrol on cytokine levels and oxidative stress in intestinal ischemia/reperfusion injuries.METHODS: To induce intestinal I/R, the superior mesenteric artery was occluded for 30 min and then reperfused for 150 min or 24 h. The therapeutic effects of resveratrol on the damage from intestinal ischemia/reperfusion were investigated using an isolated organ bath, along with oxidant/antioxidant and inflammatory factors such as glutathinone (GSH), malondialdehyhde (MDA), myeloperoxidase (MPO), interleukin-1β (IL-1β), and tumor necrosis factor alpha (TNF-α).RESULTS: Ischemia/reperfusion (I/R) control animals demonstrated severe deterioration of smooth muscle motor function as a significant decrease in KCl- and Ach-induced acontractile responses, high oxidative stress as an increase in lipid peroxidation and a decrease in GSH level, and an increase of MPO, IL-1β, and TNF-α activity. Pretreatment of animals with resveratrol restored intestinal dysfunction; reduced elevated MDA, MPO, IL-1β, and TNF-α levels; and reversed the depleted intestine GSH levels after both 150 min and 24 h reperfusion periods.CONCLUSIONS: The results indicated that resveratrol can reverse the effects of disrupted smooth muscle contractility, probably due to its antioxidant and anti-inflammatory effects on MPO, IL-1β, and TNF-α activities.
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