Supplementation of resveratrol in patients with T2DM and coronary heart disease had beneficial effects on glycemic control, HDL-cholesterol levels.

PMID: 

Food Funct. 2019 Sep 5. Epub 2019 Sep 5. PMID: 31486447

Abstract Title: 

The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease.

Abstract: 

This study was performed to investigate the effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). This randomized, double-blind, placebo-controlled trial was performed with 56 patients having T2DM and CHD. The patients were randomly divided into two groups to receive either 500 mg resveratrol per day (n = 28) or placebo (n = 28) for 4 weeks. Resveratrol reduced fasting glucose (β -10.04 mg dL-1; 95% CI, -18.23, -1.86; P = 0.01), insulin (β -1.09 μIU mL-1; 95% CI, -1.93, -0.24; P = 0.01) and insulin resistance (β -0.48; 95% CI, -0.76, -0.21; P = 0.001) and significantly increased insulin sensitivity (β 0.006; 95% CI, 0.001, 0.01; P = 0.02) when compared with the placebo. Resveratrol also significantly increased HDL-cholesterol levels (β 3.38 mg dL-1; 95% CI, 1.72, 5.05; P

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