PMID:
Sr Care Pharm. 2019 May 1 ;34(5):325-333. PMID: 31054591
Abstract Title:
Effects of Chronic Proton-Pump Inhibitor Use on Kidney Function in Older Adults.
Abstract:
Proton-pump inhibitors (PPIs) have been associated with adverse renal outcomes in older adults; however, there are little data regarding the magnitude of the change in renal function in this population. The objective of this study was to quantify the change in kidney function associated with chronic PPI therapy at two years in older adults using estimated glomerular filtration rate (eGFR).The study was a retrospective, pre/post, observational cohort.The study included University of Colorado Health primary care patients 60 to 89 years of age who were newly initiated on a PPI between August 1, 2012, and March 1, 2015, and remained on therapy for at least two years. The primary outcome was the change in kidney function, measured by eGFR, two years after starting PPI therapy. Secondary outcomes included change in kidney function and incidence of reduction in eGFR to
Health Time 