PMID:
Anc Sci Life. 2016 Oct-Dec;36(2):98-103. PMID: 28446831
Abstract Title:
Antinociceptive and Antioxidant Activities of the Methanolic Extract ofSeeds.
Abstract:
CONTEXT: The seeds ofhave been known to possess different biological properties and are used in traditional medicine in Africa and Asia to treat many ailments. The plant is particularly noted traditionally for its healing properties and is usually consumed in the form of herbal decoctions/concoctions as a blood tonic, to treat sudden attacks of convulsions, pain, malaria and anaemia.AIMS: In the present study, various phytochemical and pharmacological studies were done on the methanolic extract of the seeds ofto evaluate its antioxidant and antinociceptive properties to substantiate its traditional use.METHODS: Phytochemical screening of the extract was done according to standard procedures. Antioxidant potential was ascertained using 2,2-diphenyl-1-picryl hydrazyl (DPPH) scavenging activity, total phenolic content and total flavonoid content assays. Analgesic activity was analyzed using formalin induced paw licking test in albino rats at 100, 200 and 400 mg extract per kg body weight.STATISTICAL ANALYSIS USED: All results extrapolated from the experiments were expressed as mean± SEM. Data obtained was analyzed statistically using ANOVA (one-way) followed by Dennett's posthoc test.RESULTS: Phytochemicals present in the extract were alkaloids, flavonoids, saponins, terpenoids, steroid and anthraquinones. The extract significantly inhibited DPPH scavenging activity with percentage inhibition of 147.3%. The methanolic seed extract ofsignificantly reduced (
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