PMID:
Complement Ther Med. 2019 Oct ;46:81-86. Epub 2019 Aug 4. PMID: 31519292
Abstract Title:
Effect of Berberine on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials.
Abstract:
OBJECTIVES: Clinical evidence suggests the beneficial effects of Berberine (BER) on inflammatory markers. However, these results are controversial. The aim of this systematic review was to assess the effects of BER on C-reactive protein (CRP) using clinical trials in adults.DESIGN: Systematic review and meta-analysis.MAIN OUTCOME MEASURES: We searched randomized controlled trials in PubMed and Scopus up to November 2018. The mean differences (MD) and confidence interval (CI) of CRP (mg/L) concentrations were pooled with a random- or a fixed-effects model depending on the results of heterogeneity tests.RESULTS: Of 1242 studies identified, 5 were included in the meta-analysis. Pooled analysis showed that serum levels of CRP were decreased after BER supplementation (MD:-0.64 mg/L, 95% CI(-0.67 to -0.61) P
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