PMID:
Int J Mol Sci. 2019 Jul 17 ;20(14). Epub 2019 Jul 17. PMID: 31319552
Abstract Title:
Suppression of-Induced Skin Inflammation byExtract and Its Major Constituent Eucalyptol.
Abstract:
Acne is an inflammatory skin disorder in puberty with symptoms including papules, folliculitis, and nodules.() is the main anaerobic bacteria that cause acne. It is known to proliferate within sebum-blocked skin hair follicles.activates monocytic cell immune responses to induce the expression of proinflammatory cytokines. Although the anti-inflammatory function of the() extract (LNE) on several immunological disorders have been reported, the effect of LNE in-mediated skin inflammation has not yet been explored. In the present study, we examined the ability of the LNE to modulate the-induced inflammatory signaling pathway, and evaluated its mechanism. LNE significantly suppressed the expression of-mediated proinflammatory cytokines, such as IL-1β, IL-6, and NLRP3. We also found that LNE inhibited the inflammatory transcription factor NF-κB in response to. In addition, eucalyptol, which is the main constituent of LNE, consistently inhibited-induced inflammatory signaling pathways. Moreover, LNE significantly ameliorated-induced inflammation in a mouse model of acne. We suggest for the first time that LNE hold therapeutic value for the improvement of-induced skin inflammation.
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