Association of opioid use in the week before death among patients with advanced lung cancer having sepsis.

PMID: 

Cancer Control. 2019 Jan-Dec;26(1):1073274819871326. PMID: 31452400

Abstract Title: 

Association of Opioid Use in the Week Before Death Among Patients With Advanced Lung Cancer Having Sepsis.

Abstract: 

Opioid use can induce immunosuppression; however, it is unclear whether opioid use increases infections in patients with advanced cancers. This study assessed the association between opioid use in the week before death and mortality among patients with advanced lung cancer having sepsis. Data on opioid usage in the week before death, general information, and clinical information of the patients were collected retrospectively. The primary outcome was the association between opioid use in the week before death and mortality after sepsis. The study included 980 patients who died of advanced lung cancer between January 2003 and June 2017 (sepsis related: 413, unrelated to sepsis: 567). The average morphine equivalent daily dose in the final week was higher in the sepsis group (313.5± 510.5 mg) than in the nonsepsis group (125.2 ± 246.9 mg,

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