PMID:
J Appl Physiol (1985). 2019 Jul 25. Epub 2019 Jul 25. PMID: 31343948
Abstract Title:
Beet the cold: Beetroot juice improves peripheral blood flow, endothelial function and anti-inflammatory status in individuals with Raynaud's phenomenon.
Abstract:
Raynaud's phenomenon (RP) is characterised by recurrent transient peripheral vasospasm and lower nitric oxide (NO) bioavailability in the cold. We investigated the effect of nitrate-rich beetroot juice (BJ) supplementation onNO-mediated vasodilation,cutaneous vascular conductance (CVC) and skin temperature (T) following local cooling andsystemic anti-inflammatory status. Following baseline testing, twenty-three individuals with RP attended four times, in a double-blind, randomized crossover design, following acute and chronic (14 days) BJ and nitrate-depleted beetroot juice (NDBJ) supplementation. Peripheral Tand CVC were measured during and after mild hand and foot cooling, and during transdermal delivery of acetylcholine and sodium nitroprusside. Markers of anti-inflammatory status were also measured. Plasma [nitrite] was increased in the BJ conditions (0.05). Plasma [interleukin-10] was greater, pan endothelin and systolic and diastolic blood pressure (BP) were reduced, and forearm endothelial function was improved ,by both BR and NDBJ supplementation (
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