PMID:
BMC Complement Altern Med. 2019 Feb 20 ;19(1):49. Epub 2019 Feb 20. PMID: 30786935
Abstract Title:
Protective effects of triple fermented barley extract (FBe) on indomethacin-induced gastric mucosal damage in rats.
Abstract:
BACKGROUND: Hordeum vulgare L (barley) contains numerous phenolic substances with proven anticancer, antioxidant and gastroprotective activities. Saccharification increases the functionality and bioavailability of these compounds thus can aid in the development of a natural product based medicine. This study aimed to investigate the possible gastroprotective effects of saccharification on the indomethacin (IND)-induced gastric ulcers in rats using Weissella cibaria- and Saccharomyces cerevisiae-triple fermented H. vulgare extract (FBe).METHODS: In total, 60 healthy male 6-week old Sprague-Dawley SD (SPF/VAF Outbred CrljOri:CD1) rats were commercially purchased. The FBe extract (100, 200, and 300 mg kg) was orally administered 30 min before an oral treatment of IND (25 mg kg). Six hours after IND treatment, variations in the histopathology, myeloperoxidase (MPO) activity, gross lesion scores, lipid peroxidation, and antioxidant defense system component (superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH)) levels were measured.RESULTS: FBe treatment showed significant (p
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