PMID:
Curr Opin Pharmacol. 2019 Oct 4 ;48:120-126. Epub 2019 Oct 4. PMID: 31590111
Abstract Title:
Microbial regulation of microRNA expression in the brain-gut axis.
Abstract:
The gut microbiome facilitates a consistent transfer of information between the gut and the brain and microRNAs may now represent a key signalling molecule that facilitates this relationship. This review will firstly examine how these small non-coding RNAs influence the gut microbiome, and secondly how the microbiome, when disturbed, may influence miRNA expression in the brain. In addition, we will examine the consequence that microbiome-related changes in miRNA expression have on neurodevelopment, behaviour and cognition. We will also discuss novel data that suggests miRNAs contained in our diet may influence our immune system in a positive manner, offering a further potential pathway for treatment of disorders of the gut-brain axis that are influenced by the microbiome.
Health Time 