PMID:
Rejuvenation Res. 2019 Oct 8. Epub 2019 Oct 8. PMID: 31591931
Abstract Title:
Dietary intake ofβ-glucans can prolong lifespan and exert an anti-oxidant action of aged fish Nothobranchius guentheri.
Abstract:
One of the widely accepted conjectures regarding mechanisms of aging is probably the oxidative stress hypothesis.β-1,3-Glucans, well-known immunostimulants, have been shown to increase non-specific immunity and resistance against infections or pathogenic bacteria in several fish species, but its anti-aging function remains poorly understood. By feeding of β-1,3-glucans to the annual fish Nothobranchius guentheri, we detected the survivorship of the fish and estimated the development of age-related biomarkers at different stages. We first showed that administration of β-1,3-glucans was able to prolong the life span of the fish (p
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