PMID:
Int J Food Sci Nutr. 2019 Sep 23:1-14. Epub 2019 Sep 23. PMID: 31544542
Abstract Title:
Antiproliferative and antioxidant effect of polar hemp extracts (L., Fedora.) in human colorectal cell lines.
Abstract:
Total phenolic content and antioxidant activity of polar extracts of edible resources from Fedora hemp cultivar (L.), namely seed, flour and oil, were evaluated. The main components in the polar extracts were identified using HPLC-DAD and HPLC-ESI-MS/MS. As expected, the molecular profile of components from seeds and flour was strictly similar, dominated by N-trans-caffeoyltyramine. The profile of oil polar extracts contained hydroxycinnamic acid derivatives and cannabinoids at lower extent. While the extracts from hemp seed and flour did not interfere with growth of Caco-2 and HT-29 cell, the one from oil (150 µg/mL) significantly reduced cell viability after 24 h of treatment. This effect was associated with the activation of apoptotic cell death and was independent from the antioxidant capacity of the oil polar extract. Notably, HT-29 cells differentiated with sodium butyrate were not sensitive tothe cytotoxic effect of the oil extract.
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