Study of the mechanism of anti-ulcer effects of virgin coconut oil on gastric ulcer-induced rat model.

PMID: 

Arch Med Sci. 2019 Sep ;15(5):1329-1335. Epub 2018 Jul 5. PMID: 31572481

Abstract Title: 

Study of the mechanism of anti-ulcer effects of virgin coconut oil on gastric ulcer-induced rat model.

Abstract: 

Introduction: This study aims to evaluate the gastro-protective effects of virgin coconut oil (VCO) on different ulcer models as compared to the standard drug (omeprazole).Material and methods: Three groups of rats (6 rats per group for each ulcer model) were pre-treated with distilled water for the negative control group, 30 mg/kg of omeprazole for the positive control group and VCO (2 ml per rat) for the treatment group. Animals were pre-treated for 7 days and ulcers were induced with cold restraint stress, piroxicam, ethanol and pylorus ligation. On day eight, animals were sacrificed and ulcer scores were determined based on macroscopic evaluation. The gastric volume, pH, total acidity and mucus content were measured in the pylorus-ligated model. The levels of antioxidants were determined from the gastric tissue homogenates.Results: Virgin coconut oil significantly (

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