PMID:
J Sci Food Agric. 2019 Oct 23. Epub 2019 Oct 23. PMID: 31646650
Abstract Title:
Pomegranate juice improves the cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: A randomized crossover trial.
Abstract:
BACKGROUND: Pomegranate has antioxidant, cardioprotective, and anti-inflammatory properties. We designed a crossover study, aimed to determine if consumption of pomegranate juice (PJ) improves lipid profile and oxidative and inflammatory biomarkers of hemodialysis patients. Forty-one hemodialysis patients were randomly assigned to one of the two groups: PJ-treated group receiving 100 ml natural PJ immediately after their dialysis session three times a week and the control group receiving the usual care. After 8 weeks, a 4-week washout period was established and then the role of the groups was exchanged. Lipid profile, blood pressure, and oxidative and inflammatory biomarkers were measured before and after each sequence.RESULTS: Based on the results of intention-to-treat analysis, triglycerides were decreased in PJ condition and increased in the controls. Conversely, high-density lipoprotein (HDL)-cholesterol was increased in PJ and decreased in the control group. Total and low-density lipoprotein (LDL)-cholesterol did not significantly change in either condition. Systolic and diastolic blood pressure significantly decreased in PJ condition. Total antioxidant capacity increased in PJ condition (P
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