PMID:
Infect Disord Drug Targets. 2019 Jun 26. Epub 2019 Jun 26. PMID: 31241441
Abstract Title:
Therapeutic value of Vitamin D as an adjuvant therapy in neonates with sepsis.
Abstract:
: Sepsis is an unusual systemic reaction to what is sometimes an otherwise ordinary infection, and it probably represents a pattern of response by the immune system to injury. Vitamin D is a fat-soluble steroid hormone that contributes to the maintenance of normal calcium homeostasis and skeletal mineralization. Vitamin D has an important role in the regulation of both innate and adaptive immune systems.AIM OF THE WORK: Current study aimed to evaluate the therapeutic value of vitamin D supplementation as an adjuvant therapy in neonates with sepsis.SUBJECTS AND METHOD: This study included 60 neonates with sepsis who were divided into 2 equal groups; group I: 30 neonates with sepsis who received antibiotic only, Group II: 30 neonates with sepsis who received antibiotic therapy and vitamin D. This study included also 30 healthy neonates as a control group. Serum level of 25 (OH) vitamin D and highly sensitive C reactive protein (hs-CRP) were immunoassayed.RESULTS: There is no significant difference between group I, II and controls as regard weight, gestational age, sex and mode of delivery. There were significant differences between group I and group II in sepsis score and hs-CRP after 3, 7, 10 days of treatment (p values for sepsis score were 0.009, 0.006, 0.004 respectively and for hs-CRP were 0.015,0.001,0.001 respectively).There was significance difference in immature /total (I/T) ratio after 7,10 days of treatment (p value= 0.045, 0.025 respectively) while there was no significance difference in immature /total (I/T) ratio after 3 days of treatment (p value = 0.624). Serum 25(OH) vitamin D levels was significantly lower in neonates with sepsis (group I and II) than controls (p value
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