PMID:
Curr Comput Aided Drug Des. 2019 Oct 25. Epub 2019 Oct 25. PMID: 31654519
Abstract Title:
Benefit of passion fruit as an anti-ulcerogenic diet: Scientific evidence by in-vitro and in-silico H+/K+ATPase inhibitory activity assessment.
Abstract:
BACKGROUND: H+/K+ ATPase a well-known protein present in the parietal cells is a better target for the prevention and treatment of the disease. Flavonoids have been reported to elicit beneficial effect by inhibiting the proton pump as well as by antioxidant mechanism.METHODOLOGY: In this study chloroform fraction of hydro-alcoholic extract of passion fruit was screened for proton pump inhibitory assay using goat parietal cell. Report and conclusion: The flavonoid rich fruit possess a good radical scavenging activity against DPPH. 10.41µg/mL is sufficient to inhibit the 50% activity of the ATPase enzyme of goat parietal cell. A synergistic activity was also achieved by the fruit with sub-effective doses of lansoprazole. Fenton's oxidation was also protected by the fruit induced by H2O2. Including the in-silico findings, the beneficial potency of passion fruit in curing ulcer has been evidenced and perhaps the fruit can be a good dietary supplement for the prevention and its associated complications.
Health Time 