PMID:
FASEB J. 2002 Nov ;16(13):1738-48. PMID: 12409316
Abstract Title:
High glucose-induced oxidative stress and mitochondrial dysfunction in neurons.
Abstract:
The current study examines the association between glucose induction of reactive oxygen species (ROS), mitochondrial (Mt) depolarization, and programmed cell death in primary neurons. In primary dorsal root ganglion (DRG) neurons, 45 mM glucose rapidly induces a peak rise in ROS corresponding to a 50% increase in mean Mt size at 6 h (P