PMID:
Biosci Biotechnol Biochem. 2019 Nov ;83(11):1992-1999. Epub 2019 Jul 31. PMID: 31362597
Abstract Title:
Paeonol protects against hypertension in spontaneously hypertensive rats by restoring vascular endothelium.
Abstract:
The present study focused on the effect of paeonol, one of the main components of Guizhi Fuling Pill, on blood pressure, cerebral blood flow, and vascular endothelium injury in spontaneously hypertensive rats to provide theoretical basis for the treatment of hypertension. After treatment with paeonol, the mean arterial pressure (MAP) of LSHRT and HSHRT rats decreased gradually with the prolongation of treatment time. The systolic blood flow velocity (Vs), diastolic blood flow velocity (Vd) and mean blood flow velocity (Vm) were significantly increased after paeonol treatment (
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