PMID:
Biomed Res Int. 2019 ;2019:4516730. Epub 2019 Jul 18. PMID: 31396529
Abstract Title:
Assessment of the Protective Effect ofagainst Aluminum-Induced Liver and Kidney Effects in Albino Rat.
Abstract:
Background and Objectives: Environmental pollution with the different Aluminum (Al) containing compounds has been increased. Liver and kidney are two vital organs targeted by Al accumulation. The aim of this study was to assess the possible protective and curative effects ofLinn (LS) against Al-induced impairment of liver and kidney in albino rat and to explore the mechanism behind this effect.Materials and Methods: This experimental animal-based study included fifty albino rats divided into five groups, the control, LS-treated (20 mg/kg), AlCl-treated (10 mg/kg), AlClthen LS, and AlClplus LS-treated, simultaneously for 8 weeks. At the end of the experiment, hepatic and renal functions as well as the biomarkers of antioxidants activities were assessed in the serum. Both liver and kidney were dissected out and histopathologically examined.Results: This study showed that administration of AlClcaused a significant (p