PMID:
Afr J Tradit Complement Altern Med. 2017 ;14(3):142-146. Epub 2017 Mar 1. PMID: 28480425
Abstract Title:
BEHAVIORAL EVIDENCE OF ANTIDEPRESSANT-LIKE ACTIVITY OFL. VAR.IN MICE.
Abstract:
BACKGROUND: Currently-available antidepressant agents produce various adverse effects, and are expensive. At present, various plants are being evaluated for their possible role against numerous diseases, and no doubt, the role of traditional and complementary medicines in the development of effective therapy is incredible. The present study was designed to evaluate antidepressant-like activity ofL. Var.at different doses in mice.MATERIALS AND METHODS: Antidepressant potential of ethanolic extract ofL. was evaluated at three different doses 250 mg/kg, 500 mg/kg and 1000 mg/kg by using forced swim test and tail suspension test on albino male mice. The results were compared with control and standard mice groups administered with normal saline and Fluoxetine respectively. In both parameters immobility period was recorded two times during 60 days dosing.RESULTS: The ethanol extract at all three tested doses (250 mg/kg, 500 mg/kg and 1000 mg/kg) and standard fluoxetine demonstrated notable antidepressant-like activity (p
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