PMID:
Int J Vitam Nutr Res. 2019 Nov 12:1-16. Epub 2019 Nov 12. PMID: 31711376
Abstract Title:
The relationship between vitamin D deficiency and oxidative stress can be independent of age and gender.
Abstract:
The active vitamin D (1,25(OH)D) acts through a nuclear receptor to perform several functions in cellular metabolism. 1,25(OH)D participates directly in calcium homeostasis, regulates the immune system, nervous system, blood pressure, insulin secretion, among others. Vitamin D deficiency could also be associated with several diseases and increased cellular oxidative damage. The present study aimed to investigate whether lipid peroxidation and/or protein oxidation are affected by vitamin D deficiency and whether sunlight exposure/diet, gender, and age might influence this relationship. Vitamin D concentrations were obtained from the Heart Hospital database and a questionnaire was applied among the 212 participants. We used the inactive vitamin D (25(OH)) in the analyses since 1,25(OH)D has a short half-life and a low blood concentration. Lipid peroxidation and protein oxidation analyses were performed using spectrophotometry. Multivariate analyses suggested the participation of vitamin D deficiency (
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