PMID:
J Clin Med. 2019 Nov 11 ;8(11). Epub 2019 Nov 11. PMID: 31718054
Abstract Title:
The Effects of Postoperative Astaxanthin Administration on Nasal Mucosa Wound Healing.
Abstract:
: .BACKGROUND: Wound healing of the nasal mucosa after endoscopic sinus surgery (ESS) is frequently complicated by scaring and consequently recurrences are encountered. Methods of optimizing results have been sought. In the present study we evaluated the effects of a powerful antioxidant, astaxanthin, on nasal mucosa healing after surgery, comparing it to the extensively studied properties of dexamethasone.MATERIALS AND METHODS: 63 Wistar rats were used. The nasal mucosa from one side was damaged employing the brushing method. They were randomly divided into three experimental groups, one treated with astaxanthin, the second treated with dexamethasone and the third one acted as the control and was given normal saline. The rats were killed on days 5, 14 and 28 following injury. We observed the temporal evolution of the wound healing process and quantified the results by assessing four parameters: the epithelial thickness index (ETI), the subepithelial thickness index (STI), the goblet cell count and the subepithelial fibrosis index (SFI).RESULTS: At 28 days, the ETI was significantly lower in the astaxanthin group (p
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