PMID:
J Pak Med Assoc. 2019 Aug ;69(Suppl 3)(8):S88-S92. PMID: 31603885
Abstract Title:
Berberine attenuates olanzapine induced-metabolic syndrome.
Abstract:
Objective: To elucidate the protective effect of berberine on olanzapine induced-metabolic syndrome.Methods: This prospective experimental study involved thirty Sprague-Dawley male rats which were divided into three groups. Group A (n=10): Rats treated with distilled water, Group B (n=10): Rats treated with olanzapine, Group C (n=10): Rats treated with olanzapine plus berberine. The duration of the study was 8 weeks, baseline and follow up data were evaluated. Fasting blood glucose(FBG) total cholesterol (TC), triglyceride (TG) and high-density lipoprotein (HDL), Low density lipoprotein (LDL), atherogenic index of plasma (AI), fasting serum insulin level, insulin resistance,β- cell function and insulin sensitivity were evaluated.SPSS 20.Results: Olanzepine led to significant deterioration in gluco-metabolic profile compared with control P
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