PMID:
Drug Chem Toxicol. 2019 Aug 30:1-11. Epub 2019 Aug 30. PMID: 31469002
Abstract Title:
Fluted pumpkin seeds protect against busulfan-induced oxidative stress and testicular injuries in adult mice.
Abstract:
Fluted pumpkin is traditionally claimed to improve fertility health of male adult subjects. This study evaluated the adjuvant protective potential of fluted pumpkin seeds (FPS) extract on the deleterious effects of busulfan on the testes. Tubular germ cell depletion was induced in the testis of mice byadministration of busulfan (15 mg/kg body wt. two injections, seven days apart) and the effect of ethanolic extract of FPS (200 mg/kg body wt.) was investigated after 40 days of oral administration. Busulfan caused extensive damage to the seminiferous epithelium, decreased Johnsen's score index for spermatogenesis and number of Leydig cells (
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