Propolis exhibits good hepatoprotective and antioxidant potential against furan-induced hepatocellular damage.

PMID: 

J Vet Res. 2019 Sep ;63(3):423-431. Epub 2019 Sep 13. PMID: 31572824

Abstract Title: 

Protective Role of Propolis on Low and High Dose Furan-induced Hepatotoxicity and Oxidative Stress in Rats.

Abstract: 

Introduction: The aim of this study was to evaluate potential protective effects of propolis on furan-induced hepatic damage by assessing the levels of malondialdehyde (MDA) and reduced glutathione (GSH), antioxidant enzyme activities, and histopathological changes in the liver.Material and Methods: Albino Wistar rats were divided into six groups: a control, propolis-treated (100 mg/kg b.w./day), low-dose furan-treated (furan-L group; 2 mg/kg b.w./day), high-dose furan-treated (furan-H group; 16 mg/kg b.w./day), furan-L+propolis treated, and furan-H+propolis treated group. Propolis and furan were applied by gavage; propolis for 8 days, and furan for 20 days in furan-L groups and 10 days in furan-H groups.Results: While MDA levels were elevated in furan-treated groups, levels of GSH and activities of antioxidant enzymes decreased (p

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