PMID:
Biomed Res Int. 2019 ;2019:9276831. Epub 2019 Nov 20. PMID: 31828147
Abstract Title:
Gastrodin Ameliorates Acute Rejection via IRE1/TRAF2/NF-B in Rats Receiving Liver Allografts.
Abstract:
Background: Liver transplantation (LT) is currently an effective treatment for end-stage liver disease, but the occurrence of acute rejection (AR) is still the main problem to be solved. The present study aimed to evaluate the effect of gastrodin (GAS) on LT.Methods: Rat transplant models were established and divided into SHAM, LT, GAS-L (50 mg/kg GAS), and GAS-H (100 mg/kg GAS) groups. The liver function, inflammatory factors, liver histopathology, survival of rats, number of M2-type macrophages, liver cell apoptosis, and pathway proteins were assayed at 7 days and 14 days after the operations.Results: With increasing GAS concentrations, liver function, expression of proinflammatory factors in the liver, and expression of M2-type molecules in macrophages were significantly improved, and the survival time of rats was significantly prolonged (
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