PMID:
J Food Biochem. 2019 Dec 10:e13108. Epub 2019 Dec 10. PMID: 31823399
Abstract Title:
Nigella sativa (black seed) oil ameliorates CCl-induced hepatotoxicity and mediates neurotransmitter levels in male Sprague Dawley albino rats.
Abstract:
The liver is a metabolically active organ which is prone to oxidative damage. The hepatoprotective effect of Nigella sativa (black seed oil extract) on carbon tetrachloride (CCl)-induced hepatotoxicity in Sprague-Dawley albino rats was determined. There were four groups of eight rats; Group 1 (control) was administered with distilled water for 28 days, Group 2 was administered with 4 ml/kg of CCl(70% olive oil: 30% CCl) on alternate days for 28 days. Group 3 was administered with 4 ml/kg of CCl(70% olive oil: 30% CCl) and 2 ml/kg of Nigella sativa oil orally for 28 days. Group 4 was administered with 4 ml/kg of CCl(70% Olive oil: 30% CCl) and 4 ml/kg of Nigella sativa oil orally for 28 days. Blood samples were collected for biochemical assessment. Liver, kidney, and brain tissues were determined for antioxidant enzymes and histopathological features. There were significant ameliorative effects of the oil extract in the treatment groupscompared to control (p
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