PMID:
Vaccine. 2015 Apr 21 ;33(17):2004-8. Epub 2015 Mar 18. PMID: 25795257
Abstract Title:
C-reactive protein response to influenza vaccination as a model of mild inflammatory stimulation in the Philippines.
Abstract:
BACKGROUND: C-reactive protein (CRP) is increasingly measured as a marker of systemic inflammation that predicts elevated risk for cardiovascular disease. Influenza vaccination is a mild pro-inflammatory stimulus, and the CRP response to vaccination may provide additional information on individual differences in inflammatory response and risk for disease.AIM: To document the pattern of CRP response to influenza vaccination among a large sample of older women in the Philippines. The Philippines exemplifies current global trends toward increasing rates of overweight/obesity, but also maintains relatively high rates of infectious disease. The secondary aim of the study is to investigate the impact of infectious symptoms on the pattern of response to vaccination.METHODS: A community-based sample of 934 women (mean age=55.4 years) received the influenza vaccine. CRP was assessed at baseline and 72h post-vaccination. Descriptive, non-parametric, and parametric analyses were implemented to assess the magnitude of CRP response, and to investigate whether responses were associated with baseline CRP or the presence of infectious symptoms prior to vaccination.RESULTS: Influenza vaccination resulted in a statistically significant CRP response of 0.35mg/L (p
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