PMID:
Photodiagnosis Photodyn Ther. 2019 Dec 10:101621. Epub 2019 Dec 10. PMID: 31841687
Abstract Title:
Photobiomodulation and photodynamic therapy for the treatment of oral mucositis in patients with cancer.
Abstract:
BACKGROUND: Photobiomodulation therapy (PBM-T) can penetrate soft tissues and exert analgesic and healing effects, and is thus a promising alternative for prevention and treatment of oral mucositis (OM). The aim of this study was to evaluate the efficacy of PBM-T, alone or combined with photodynamic therapy (PDT), for treatment of OM in cancer patients.METHODS: Fifty-six patients were recruited from the Oncology Department of a teaching hospital. Patients underwent grading of OM and were divided into two groups (n = 28 each): PBM-T and PBM-T + PDT. In the PBM-T group, low-level laser was applied to 61 points in the oral cavity, once weekly for 4 weeks (wavelength 660 nm, power 100 mW, energy density 142 J/cm², spot energy 4 J, irradiation time 40 seconds). In the PBM-T + PDT group, in addition to PBM-T as described above, patients rinsed with 20 mL of photosensitizing mouthwash (curcumin 1.5 g/L) and the oral cavity was irradiated with a blue (468 nm) LED for 5 min.RESULTS: Significant reductions in OM grade were observed after application of PBM-T or PBM-T + PDT (p
Health Time 