Aluminum hydroxide can precipitate persistent itching granulomas. This study reported that 5 children’s symptoms did not resolve within the 8 year observation period.

PMID: 

Contact Dermatitis. 1992 May ;26(5):304-6. PMID: 1395591

Abstract Title: 

Vaccination granulomas and aluminium allergy: course and prognostic factors.

Abstract: 

21 children who had cutaneous granulomas following immunization with a vaccine containing aluminium hydroxide, and who had positive patch tests to aqueous aluminium chloride and/or to a Finn Chamber, were followed for 1 to 8 years. During the period of observation, the symptoms cleared in 5 children, improved in 11, and remained unchanged in 5. The course of the granulomas could not be correlated with sex or atopy, nor with intensity of the initial aluminium patch test. 4 children were patch tested again with aluminium.

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