PMID:
Cardiovasc Hematol Disord Drug Targets. 2019 11 19. Epub 2019 Nov 19. PMID: 31746299
Abstract Title:
Ethyl acetate and aqueous fractions of Ziziphus jujuba prevent acute hypertension induced by angiotensin II in rats.
Abstract:
BACKGROUND: Antihypertensive effect of Ziziphus jujube (ZJ) has been reported previously.OBJECTIVE: The present study investigates the effect of two ethyl acetate (polar and semi-polar compound) and aqueous fractions (polar compound) of ZJ on cardiovascular parameters in acute hypertension induced by angiotensin II(AngII).METHODS: Rats randomly were divided into as following groups (n=7 in each group): Control, AngII (50 ng/kg), Losartan (Los, 30 mg/kg) + AngII, ethyl acetate fraction (EA150 and EA300 mg/kg) + AngII and aqueous fraction (A150 and A300 mg/kg) + AngII. Treated rats received Los and ZJ fractions for four weeks orally and in experiment day (28th) received AngII intravenously. In all groups' systolic blood pressure (SBP), heart rate (HR) and mean arterial pressure (MAP) were recorded throughout the experiment after cannulation of femoral artery via power lab system.RESULTS: In AngII group SBP and MAP significantly increased (P
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