PMID:
J Med Case Rep. 2013 Oct 7 ;7:237. Epub 2013 Oct 7. PMID: 24099396
Abstract Title:
A young traveller presenting with typhoid fever after oral vaccination: a case report.
Abstract:
INTRODUCTION: Typhoid fever is one of the most common vaccine-preventable diseases in travellers returning from tropical destinations. However, immunity and the immune response to infection are barely understood.CASE PRESENTATION: We report a case of tyhoid fever in a 29-year-old Caucasian, previously healthy woman who did not develop protective immunity or seroconversion of H or O antibodies neither after vaccination with the oral Ty21 vaccine, nor after infection with Salmonella typhi.CONCLUSIONS: This case highlights the insufficiencies of the current vaccination and the lack of a reliable, rapid serologic diagnostic tool for typhoid fever. With this case report, we aim to sensitize the reader that typhoid fever has to be taken into account as a differential diagnosis in patients even after vaccination and with negative serological test results.
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