PMID:
Prev Nutr Food Sci. 2019 Sep ;24(3):254-264. Epub 2019 Sep 30. PMID: 31608250
Abstract Title:
Phenolic Content Analysis ofGel and Evaluation of the Effect of Aloe Gel Supplementation on Oxidative Stress and Fibrosis in Isoprenaline-Administered Cardiac Damage in Rats.
Abstract:
We evaluated the cardioprotective effect ofgel isoprenaline (ISO)-administered myocardial infarction in rats. ISO administration increased lipid peroxidation and oxidative stress in rats, which were ameliorated bygel supplementation. Our study also revealed that creatine kinase-MB (CK-MB) activities were increased in ISO-administered rats, while the activities of cellular antioxidants, such as superoxide dismutase and catalase, and glutathione concentration were decreased.gel lowered CK-MB enzyme activities and the glutathione concentration in ISO-administered rats, and increased antioxidant activities. Histopathological examination also revealed increases in thickness of the left ventricle myocardium, increases in mononuclear cell infiltrations, increased degeneration of focal areas of the endocardium, and increased fibrous tissue deposition in the heart of ISO-administered rats; whereas,prevented infiltration of inflammatory cells and reduced left ventricular fibrosis. In conclusion, we show thatsupplementation protects against development of cardiac inflammation, fibrosis, and oxidative stress in ISO-administered rats.
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