PMID:
Heliyon. 2019 Dec ;5(12):e02935. Epub 2019 Dec 4. PMID: 31872118
Abstract Title:
Protective role ofleaf extract on cardiac antioxidant status and lipid peroxidation in streptozotocin induced diabetic rats.
Abstract:
is a medicinal plant with great therapeutic potential. The leaves ofare used by Indians in herbal medicines to treat diabetes. The present study is aimed to determine the protective role ofin cardiac tissues under diabetic conditions. Diabetic rats were treated orally with methanolic extract ofleaves at a dose of 300 mg/Kg body weight for 60 days. The effect of extract on serum glucose, glycated hemoglobin, plasma insulin and the levels of thiobarbituric acid reactive substances (TBARS), hydroperoxides (HP), conjugated dienes (D), activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-reductase (GRD) and reduced glutathione content (GSH) were estiated. Metformin and atorvastatin were used as standard drugs. A significant increase in plasma insulin, activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-reductase (GRD) and reduced glutathione content (GSH) and a significant decrease in serum glucose, glycated hemoglobin, thiobarbituric acid reactive substances (TBARS), hydroperoxides (HP) and conjugated dienes (CD) were observed in the treated groups. This study evaluated the antioxidant potential of methanolic extract ofleaves. These findings suggest the protective role ofagainst oxidative stress in the heart of diabetic rats.
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