PMID:
Am J Clin Nutr. 2008 May ;87(5):1439-45. PMID: 18469269
Abstract Title:
Dietary flavonoid intake and non-Hodgkin lymphoma risk.
Abstract:
BACKGROUND: The role of dietary factors in non-Hodgkin lymphoma (NHL) risk is not yet well understood. Dietary flavonoids are polyphenolic compounds proposed to be anticarcinogenic. Flavonoids are well-characterized antioxidants and metal chelators, and certain flavonoids exhibit antiproliferative and antiestrogenic effects.OBJECTIVE: We aimed to evaluate the hypothesis that higher flavonoid intake is associated with lower NHL risk.DESIGN: During 1998-2000, we identified incident NHL cases aged 20-74 y from 4 US Surveillance, Epidemiology, and End Results cancer registries. Controls without history of NHL were selected by random-digit dialing or from Medicare files and frequency-matched to cases by age, center, race, and sex. Using 3 recently developed US Department of Agriculture nutrient-specific databases, flavonoid intake was estimated from participant responses to a 117-item food-frequency questionnaire (n = 466 cases and 390 controls). NHL risk in relation to flavonoid intake in quartiles was evaluated after adjustment for age, sex, registry, education, NHL family history, and energy intake.RESULTS: Higher total flavonoid intake was significantly associated with lower risk of NHL (P for trend
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