PMID:
FEMS Microbiol Lett. 2020 Jan 17. Epub 2020 Jan 17. PMID: 31950993
Abstract Title:
Improving Alzheimer's disease by altering Gut Microbiota in tree shrews with ginsenoside Rg1.
Abstract:
Ginsenoside Rg1 (GRg1) has neuroprotective effects on Alzheimer's disease (AD). The occurrence and progression of AD are closely related to gut microbiota. Few studies have learned the direct relationship between GRg1 and gut microbiota. In this study, we found an original way by using GRg1 in the AD model of tree shrews to research this relationship. Morris Water Maze and Immunohistochemistry were performed to test the cognition repairing function of GRg1 by tree shrews, 16S ribosomal RNA sequencing to explore the composition and abundance of gut microbiota. After GRg1 treatment, the result of Morris Water Maze showed the improvement of cognitive function, and Immunohistochemistry revealed the decrease of tau protein. Moreover, 16SrRNA sequencing results showed the abundance of Proteobacteria and Verrucomicrobia were significantly different, and Lactobacillaceae was significantly increased in GRg1 treatment group. It also showed the gut microbiome with middle and high dose of GRg1 was close to the normal group. In conclusion, this study suggests that GRg1 with middle and high dose may change the abundance of gut microbiota to improve AD, Proteobacteria and Verrucomicrobia are key microbiota. This is the first report that has ever studied the relationship between GRg1 and gut microbiota on tree shrews.
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